Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A myogenic switch. Muscle development

M V Taylor1

  • 1Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK.

Current Biology : CB
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation.

Experimental neurology·2016
Same author

Psychosocial impact of heart transplantation on spouses.

Clinical nursing research·2002
Same author

Muscle development: molecules of myoblast fusion.

Current biology : CB·2000
Same author

Drosophila dumbfounded: a myoblast attractant essential for fusion.

Cell·2000
Same author

A novel Drosophila, mef2-regulated muscle gene isolated in a subtractive hybridization-based molecular screen using small amounts of zygotic mutant RNA.

Developmental biology·2000
Same author

Different levels, but not different isoforms, of the Drosophila transcription factor DMEF2 affect distinct aspects of muscle differentiation.

Developmental biology·1999
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

The transcription factor Twist plays a new role in a myogenic switch during early Drosophila development. Experiments manipulating Twist levels reveal its function in this crucial developmental process.

Area of Science:

  • Developmental biology
  • Molecular biology
  • Genetics

Background:

  • The basic helix-loop-helix (bHLH) transcription factor Twist is crucial for various developmental processes.
  • Its precise role in initiating muscle development requires further elucidation.

Purpose of the Study:

  • To investigate the function of the transcription factor Twist in early Drosophila embryogenesis.
  • To identify novel roles of Twist in developmental pathways, specifically muscle formation.

Main Methods:

  • Genetic manipulation of Twist gene expression levels in Drosophila embryos.
  • Analysis of developmental phenotypes associated with altered Twist activity.

Main Results:

  • Twist acts as a key regulator in a 'myogenic switch' during early Drosophila development.

Related Experiment Videos

  • Altering Twist levels directly impacts the initiation of muscle development pathways.

    • Conclusions:

    • The transcription factor Twist is essential for initiating the myogenic switch in Drosophila.
    • These findings uncover a novel function for Twist in regulating muscle development.