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Two steps to binding replication origins? DNA-protein interactions
1Microbiology Department, Hearst Research Foundation and Howard Hughes Medical Institute, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA.
Current Biology : CB
|August 1, 1996
Abstract:
Recent structural studies of the Epstein-Barr virus EBNA1 protein bound to DNA suggest that it binds to DNA replication origins in a two-step process; the first step involves recognition of the correct sequence and the second initiates structural changes in the DNA.