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Turning off natural killers. Innate immunity
1Department of Medicine, San Francisco General Hospital and the University of California, Box 0868, San Francisco, 94143, USA.
Current Biology : CB
|September 1, 1996
Abstract:
Inhibitory receptors specific for class I molecules of the major histocompatibility complex regulate the cytolytic activity of natural killer cells. Recent studies suggest that recruitment of the protein tyrosine phosphatase SHP-1 enables these receptors to block natural killing.