Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Common entry mechanisms. Bacterial pathogenesis

A Marra1, R R Isberg

  • 1Howard Hughes Medical Institute, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA.

Current Biology : CB
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ESMO basic requirements for AI-based biomarkers in oncology (EBAI).

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Real-world safety and efficacy profiles of trastuzumab deruxtecan in patients with advanced breast cancer.

ESMO open·2025
Same author

Artificial intelligence entering the pathology arena in oncology: current applications and future perspectives.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Molecular tumour board in gastrointestinal cancers.

ESMO open·2025
Same author

Genomic and clinical landscape of metastatic hormone receptors-positive breast cancers carrying ESR1 alterations.

ESMO open·2024
Same author

FLT3-targeted therapy restores GATA1 pathway function in NPM1/FLT3-ITD mutated acute myeloid leukaemia.

EJHaem·2023
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Pathogenic bacteria like Listeria monocytogenes use host cell surface molecules for entry. Identifying E-cadherin as a receptor reveals common bacterial invasion strategies.

Area of Science:

  • Microbiology
  • Cell Biology
  • Infectious Diseases

Background:

  • Pathogenic bacteria employ diverse mechanisms to invade host cells.
  • Understanding bacterial entry pathways is crucial for developing antimicrobial strategies.

Purpose of the Study:

  • To identify the host cell surface receptor for the Listeria monocytogenes adhesin, internalin.
  • To elucidate common strategies used by pathogenic bacteria for host cell entry.

Main Methods:

  • Utilized molecular biology techniques to investigate the interaction between internalin and host cell surface proteins.
  • Performed cell-based assays to confirm E-cadherin as the specific receptor.

Main Results:

  • E-cadherin was identified as the primary cell-surface receptor for internalin.

Related Experiment Videos

  • This interaction facilitates the entry of Listeria monocytogenes into host cells.

    • Conclusions:

    • Pathogenic bacteria exploit various host surface molecules for invasion.
    • The identification of E-cadherin-internalin interaction suggests shared invasion mechanisms among pathogens.