Related Experiment Video

Updated: Aug 10, 2026

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
08:46

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis

Published on: September 16, 2014

Reading between the lines: SH3 recognition of an intact protein

W A Lim1

  • 1Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520-8114, USA.

Structure (London, England : 1993)
|June 15, 1996
PubMed

Abstract:

The structure of Nef-SH3 domain complex reveals how an SH3 domain can more effectively 'read' its linear proline-rich recognition element when it is presented within the context of a folded protein.

More Related Videos

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
08:09

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

Published on: March 24, 2017

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Related Experiment Videos

Last Updated: Aug 10, 2026

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
08:46

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis

Published on: September 16, 2014

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
08:09

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

Published on: March 24, 2017

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Related Concept Videos

Signal Sequences and Sorting Receptors01:41

Signal Sequences and Sorting Receptors

Signal sequences are short amino acid sequences that guide newly synthesized proteins to their proper location within the cell. Classical signal sequences are fifteen to sixty amino acids long and present at the N-terminus of a polypeptide chain. Each signal sequence has a conserved segment of basic residues towards their N terminus, a hydrophobic core, and a C-terminus rich in polar residues. The C-terminus also contains a signal cleavage site and features a -3 -1 sequence motif. The -3-1...

Articles linked to this work by shared authors, journal, and citation graph.

Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway.

Science (New York, N.Y.)·2018

Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins.

Molecular cell·2002

Mechanism and role of PDZ domains in signaling complex assembly.

Journal of cell science·2001

An analysis of the interactions between the Sem-5 SH3 domain and its ligands using molecular dynamics, free energy calculations, and sequence analysis.

Journal of the American Chemical Society·2001

Energetic determinants of internal motif recognition by PDZ domains.

Biochemistry·2001

Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.

Science (New York, N.Y.)·2000

Structural plasticity drives convergent evolution and functional diversification of GNAT polyamine acetyltransferases.

Structure (London, England : 1993)·2026

Structural determinants of endopilus assembly, stability, and functional specificity in bacterial type II secretion.

Structure (London, England : 1993)·2026

Morphotype-resolved 3D morphometry reveals a structure-density-location coupling in mitochondrial networks.

Structure (London, England : 1993)·2026

Cryo-EM structure of the WDR11-FAM91A1-C17orf75 complex involved in retrograde trafficking.

Structure (London, England : 1993)·2026

Conformational signatures of native ligand and pharmacochaperone binding in rhodopsin.

Structure (London, England : 1993)·2026

Ligand-dependent interdomain rearrangements drive catalysis by acetyl-CoA synthetases.

Structure (London, England : 1993)·2026

Entropy-Driven Physical Amplification in Multivalent Biosensing.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Proton Dynamics and Transport in a Protic Ionic Liquid Revealed by Multinuclear Solid-State NMR.

The journal of physical chemistry. B·2026

SPINDLE: Unlocking protein dynamics from single-field NMR relaxation data using a deep learning ensemble.

bioRxiv : the preprint server for biology·2026

Hydrophobic interactions of FG-nucleoporins are required for dilating nuclear membrane pores into selective transport channels after mitosis.

Nature structural & molecular biology·2026

Experimental Determination of the Ionization Constant of N,N‑diethylhydroxylamine (DEHA) from 25 to 250 °C at 15 MPa.

Journal of chemical and engineering data·2026

Origin of fast backward steps and detachment of kinesin motor under backward load.

Journal of theoretical biology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us