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Mucosal addressin cell adhesion molecule-1: a structural and functional analysis demarcates the integrin binding

J L Viney1, S Jones, H H Chiu

  • 1Department of Immunology, Genentech, Inc., South San Francisco, CA 94080, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|September 15, 1996
PubMed
Summary

Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) increases in inflamed intestines, mediating leukocyte trafficking. Specific residues (LDT) on MAdCAM-1 are crucial for alpha 4 beta 7 integrin binding and cell activation.

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