Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gastroesophageal reflux disease

P J Kahrilas1

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Medical School, Chicago, Ill. 60611, USA.

JAMA
|September 25, 1996
PubMed
Summary

Gastroesophageal reflux disease (GERD) management requires long-term treatment for complications like esophagitis and Barrett metaplasia, with endoscopy crucial for monitoring cancer risk. Reflux-induced asthma management remains challenging.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The 2018 ISDE achalasia guidelines.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2018
Same author

Editorial: symptom association probability during reflux testing-what is the gain?

Alimentary pharmacology & therapeutics·2018
Same author

Correlation between novel 3D high-resolution manometry esophagogastric junction metrics and pH-metry in reflux disease patients.

Neurogastroenterology and motility·2018
Same author

The relationship between esophageal acid exposure and the esophageal response to volumetric distention.

Neurogastroenterology and motility·2017
Same author

High-resolution manometry assessment of the lower esophageal sphincter after-contraction: Normative values and clinical correlation.

Neurogastroenterology and motility·2017
Same author

Editorial: when to be suspicious of malignancy-associated pseudoachalasia.

Alimentary pharmacology & therapeutics·2017

Area of Science:

  • Gastroenterology
  • Pulmonology
  • Otolaryngology

Background:

  • Gastroesophageal reflux disease (GERD) is a common condition with potential for serious esophageal and extraesophageal complications.
  • Esophageal complications include esophagitis, stricture, Barrett metaplasia, and adenocarcinoma.
  • Extraesophageal manifestations can involve otolaryngological symptoms and asthma.

Purpose of the Study:

  • To review current management strategies for GERD.
  • To focus on adults with esophageal complications (esophagitis, stricture, adenocarcinoma, Barrett metaplasia).
  • To examine management of extraesophageal complications, including otolaryngological manifestations and asthma.

Main Methods:

  • Literature review of peer-reviewed publications.
  • Emphasis on recent advancements in diagnosis and therapeutics.
  • Prioritization of controlled therapeutic trials and critical evaluation of other studies.

Main Results:

  • Esophagitis is a chronic condition managed with long-term antisecretory therapy; laparoscopic surgery is an alternative but lacks comparative data.
  • Barrett metaplasia, a precursor to adenocarcinoma, is increasing and requires surveillance.
  • Reflux can cause asthma and otolaryngological issues, with varying responses to treatment.

Conclusions:

  • Antisecretory medications manage GERD symptoms and esophagitis, but refractory cases or those with alarm symptoms need endoscopy.
  • Patients with Barrett metaplasia require ongoing surveillance to mitigate cancer risk.
  • Reflux-induced asthma presents a management challenge due to limited effective therapies.

Related Experiment Videos