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Exercise training prevents maturation-induced decrease in insulin sensitivity

N Nakai1, Y Shimomura, N Ohsaki

  • 1Research Center of Health, Physical Fitness, and Sports, Nagoya University, Japan.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1996
PubMed
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Exercise training prevents age-related decline in insulin sensitivity in rats. This improvement is linked to increased glucose transporter GLUT-4 in skeletal muscle membranes.

Area of Science:

  • Exercise Physiology
  • Metabolic Health

Background:

  • Insulin sensitivity naturally decreases with age in female rats.
  • Skeletal muscle glucose uptake is crucial for metabolic homeostasis.

Purpose of the Study:

  • To investigate the impact of exercise training timing on insulin sensitivity and GLUT-4 levels.
  • To determine if exercise can counteract age-related declines in metabolic function.

Main Methods:

  • Female Wistar rats underwent exercise training either before or after maturation.
  • Euglycemic clamp technique assessed insulin sensitivity at various ages.
  • Skeletal muscle membrane fractions were analyzed for glucose transporter GLUT-4 content.

Main Results:

  • Sedentary rats showed a significant decrease in glucose infusion rate (GIR) with age.

Related Experiment Videos

  • Exercise-trained rats maintained high GIR, unaffected by maturation or aging.
  • Starting exercise after maturation also restored GIR to trained levels.
  • Skeletal muscle GLUT-4 content mirrored the GIR trends.

    • Conclusions:

    • Exercise training effectively prevents the maturation-induced decline in insulin sensitivity.
    • Increased insulin-sensitive GLUT-4 in skeletal muscle membranes contributes to exercise-induced improvements in insulin sensitivity.