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Exercise activates renal dysfunction in hypertension

J H Clorius1, A Mandelbaum, T Hupp

  • 1German Cancer Research Center, Heidelberg, Germany.

American Journal of Hypertension
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

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Certain hypertensive patients exhibit a bilateral renal functional abnormality during exercise, identified by abnormal renograms and reduced kidney function. This exercise-induced disturbance affects glomerular filtration rate and effective renal plasma flow, impacting blood pressure regulation.

Area of Science:

  • Nephrology
  • Cardiology
  • Exercise Physiology

Background:

  • A bilateral, exercise-mediated renal functional abnormality is recognized in hypertension.
  • This disturbance is particularly studied in renovascular disease and essential hypertension.

Purpose of the Study:

  • To investigate the exercise-induced bilateral renal functional disturbance in hypertensives with unilateral renovascular disease.
  • To compare findings with normotensive and essential hypertensive controls.

Main Methods:

  • Renography at rest and during ergometric exercise (60-80 W) in 31 hypertensives with unilateral renovascular disease.
  • Infusion clearance studies using 131I-hippurate and 111In-DTPA to determine GFR and ERPF at rest and during exercise (25 W).
  • Control groups included 7 normotensives and 17 essential hypertensives.

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Main Results:

  • Eighteen of 31 hypertensives with unilateral renovascular disease showed a bilateral-abnormal exercise renogram.
  • These patients exhibited a significant reduction in GFR and a lesser decrease in ERPF during exercise.
  • 65% of essential hypertensive controls also displayed this exercise-induced functional disturbance, unlike normotensive controls.

Conclusions:

  • An exercise-mediated, bilateral renal functional disturbance is present in a subset of hypertensive patients.
  • This condition is characterized by a bilateral-abnormal exercise renogram and abnormal renal clearance during exercise, notably a low filtration fraction.
  • The findings suggest a link between exercise, renal function, and hypertension management.