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Pancreatitis post-bone marrow transplantation
1Manitoba Bone Marrow Transplant Program, Manitoba Cancer Treatment and Research Foundation, Canada.
Abstract:
Pancreatitis has been reported as a rare complication after bone marrow transplantation (BMT). This paper reports a series of three cases of pancreatitis post-BMT and reviews the literature. Pancreatitis occurred in three of 68 (4.4%) of BMT cases in our transplant program. The etiology of such cases is multifactorial and includes drugs, graft-versus-host disease, infection, cholecystitis, and the lipid in total parenteral nutrition. Pancreatitis should be included in the differential diagnosis of abdominal pain post-BMT. The development of a pancreatic pseudocyst in an immunocompromised host may require surgical drainage since infected pseudocysts are not drained adequately by radiologically guided techniques.
Insights
Pancreatitis is a rare complication following bone marrow transplantation (BMT). This study highlights its multifactorial causes and the need for its consideration in BMT patients with abdominal pain.
Area of Science:
- Hematology
- Gastroenterology
- Transplantation Medicine
Background:
- Bone marrow transplantation (BMT) is a life-saving procedure.
- Rare complications can arise post-transplant, impacting patient recovery.
- Pancreatitis is an infrequent but serious condition observed after BMT.
Observation:
- This paper details three cases of pancreatitis occurring after BMT.
- Pancreatitis was observed in 4.4% of BMT cases within the transplant program.
- The study reviewed existing literature on post-BMT pancreatitis.
Findings:
- The etiology of pancreatitis post-BMT is multifactorial.
- Identified causes include medications, graft-versus-host disease, infections, cholecystitis, and lipids from total parenteral nutrition.
- Pancreatitis must be considered in the differential diagnosis for abdominal pain in BMT recipients.
Implications:
- Early recognition and diagnosis of pancreatitis are crucial for BMT patients.
- Management strategies should address the diverse potential causes.
- Pancreatic pseudocysts in immunocompromised patients may necessitate surgical intervention, especially if infected.