Determination of citrate in plasma protein solutions by UV-visible spectrophotometry and ion chromatography

Two procedures were compared for the determination of citrate in plasma protein solution (PPS). Ion chromatography with gradient elution was preferred to an enzymatic-spectrophotometric method for citrate concentrations in the range 0.4-11 mg l-1. Better comparisons of results by both methods were obtained for citrate concentrations at the g l-1 level, as dilution of the PPS reduced interferences in the enzymatic procedure.