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Phosphate supplementation prevents a decrease of triiodothyronine and increases resting metabolic rate during low

K Nazar1, H Kaciuba-Uściłko, J Szczepanik

  • 1Department of Applied Physiology, Polish Academy of Sciences, Warsaw, Poland.

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|June 1, 1996
PubMed
Summary

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Phosphate supplementation during a low-energy diet increased resting metabolic rate (RMR) in overweight women. This dietary intervention also positively influenced thyroid hormone levels, aiding weight management.

Area of Science:

  • Human Nutrition
  • Metabolic Studies
  • Endocrinology

Background:

  • Obesity management often involves low-energy diets.
  • The role of mineral supplementation in weight loss programs requires further investigation.
  • Thyroid hormones play a crucial role in regulating metabolic rate.

Purpose of the Study:

  • To investigate the effect of phosphate supplementation on resting metabolic rate (RMR) in overweight women undergoing a low-energy diet.
  • To assess the impact of phosphate supplementation on thyroid hormone levels during a slimming program.
  • To determine if phosphate supplementation influences other metabolic markers like plasma lipids and glucose.

Main Methods:

  • A randomized, double-blind, cross-over study involving 30 overweight women.

Related Experiment Videos

  • Participants followed an 8-week low-energy diet supplemented with viscous fibers and mineral tablets (phosphates) or placebo.
  • Resting metabolic rate (RMR) and plasma thyroid hormone levels were measured.

    • Main Results:

    • Phosphate supplementation significantly increased RMR by approximately 12-19% (p < 0.05).
    • Phosphate supplementation mitigated the decrease in plasma triiodothyronine and the thyroxine to triiodothyronine ratio.
    • No significant changes were observed in plasma insulin, catecholamine, growth hormone, cortisol, testosterone, lipids, or glucose levels.

    Conclusions:

    • Phosphate supplementation enhances RMR in overweight individuals on a low-energy diet, independent of weight loss rate.
    • The observed increase in RMR appears to be partly mediated by the influence of phosphates on peripheral thyroid hormone metabolism.
    • Phosphate supplementation may be a beneficial adjunct to low-energy diets for weight management in obese individuals.