How pathogens exploit interactions mediated by SH3 domains

An important event in signal transduction is the binding of SH3 domains, found in viral proteins such as v-Src and v-Crk, to proline-rich sequences. Recently, proline-rich proteins that bind host-cell SH3 domains have been identified in a variety of pathogenic microorganisms. Exploitation of SH3-mediated interactions by pathogens may be more common than previously suspected.