Related Experiment Videos
Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story
C T Walsh1, S L Fisher, I S Park
1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Chemistry & Biology
|January 1, 1996
Abstract:
A plasmid-borne transposon encodes enzymes and regulator proteins that confer resistance of enterococcal bacteria to the antibiotic vancomycin. Purification and characterization of individual proteins encoded by this operon has helped to elucidate the molecular basis of vancomycin resistance. This new understanding provides opportunities for intervention to reverse resistance.