Exploiting the potential of antisense: beyond phosphorothioate oligodeoxynucleotides
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Updated: Nov 1, 2026

09:04
Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
1Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
Chemistry & Biology
|May 1, 1996
Abstract:
Phosphorothioate oligodeoxynucleotides, designed as nuclease-resistant antisense agents, appear to have a number of surprising biological effects that are unrelated to their intended antisense activity. These effects may be useful in themselves, but must be understood for the full potential of antisense technology to be realized.
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