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Sertraline overdose

G T Lau1, B Z Horowitz

  • 1Division of Emergency Medicine and Clinical Toxicology, University of California, Davis, Medical Center, Sacramento 95817, USA.

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
|February 1, 1996
PubMed
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Sertraline overdose typically presents with minor, short-lived symptoms like tremor, lethargy, and nausea, especially when taken with other substances. Most patients experience no significant adverse outcomes from sertraline (an antidepressant) overdose.

Area of Science:

  • Clinical Toxicology
  • Pharmacology
  • Emergency Medicine

Background:

  • Sertraline is a widely prescribed selective serotonin reuptake inhibitor (SSRI) antidepressant.
  • Overdose data for newer antidepressants like sertraline is crucial for clinical management.

Purpose of the Study:

  • To characterize the clinical presentation of presumed sertraline overdoses.
  • To identify common signs, symptoms, and outcomes associated with sertraline ingestions.

Main Methods:

  • Prospective study across five regional poison control centers.
  • Data collected on 42 sertraline ingestions over nine months.
  • Included patient demographics, coingestants, clinical signs, and outcomes.

Main Results:

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  • 40 cases of sertraline overdose analyzed; mean ingested dose 1,579 mg.
  • Isolated overdoses often asymptomatic or presented with tremor, lethargy, nausea.
  • Coingestions (benzodiazepines, alcohol) common; symptoms included lethargy, nausea, dry mouth, mydriasis.
  • No significant morbidity or adverse outcomes reported in treated or observed patients.

Conclusions:

  • Sertraline overdoses are frequently associated with coingestion of other substances.
  • Clinical manifestations of sertraline overdose are generally minor and transient.
  • Sertraline appears to have a relatively favorable safety profile in overdose.