The "clonal selection hypothesis" and current concepts of B cell tolerance

B-cell development.

Immunology today·2014

Is tolerance the result of engaging surface Ig of B cells in cycle?

Immunology today·2014

Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta.

Journal of immunology (Baltimore, Md. : 1950)·2001

Relative roles of somatic and Darwinian evolution in shaping the antibody response.

Immunologic research·2000

B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation.

Journal of immunology (Baltimore, Md. : 1950)·1999

Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chains.

Journal of immunology (Baltimore, Md. : 1950)·1998

Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism.

Immunity·2026

Group 2 innate lymphoid cells activate myelin-reactive T cells to augment neuroinflammation.

Immunity·2026

CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity.

Immunity·2026

Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors.

Immunity·2026

Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated microglia in neurodegenerative diseases.

Immunity·2026

Butyrophilin-like 3 and 8 tetramers clamp Vγ4Vδ1 T cell receptors for antigen-independent activation.

Immunity·2026

Life-Threatening Melena from Deep Ileal Angiodysplasia Successfully Treated by Intraoperative Enteroscopy-Guided Segmental Resection: A Case Report.

Surgical case reports·2026

Immune checkpoint inhibitors in the real world: A service evaluation of immune-related adverse event incidence and blood test requesting at Portsmouth Hospitals University Trust.

Annals of clinical biochemistry·2026

[Current status of methods and proficiency in assays for islet autoantibodies].

Zhonghua yi xue za zhi·2026

A biparatopic antibody targeting the Cε2 and Cε3 domains of IgE disrupts IgE-FcεRI interaction.

Journal of advanced research·2026

Advancing Type 1 Diabetes Treatment: 3 PM-Oriented Innovations in Islet Transplantation and Biomaterial Engineering.

Diabetes/metabolism research and reviews·2026

How Biologics Are Changing the Global Burden of Inflammatory Bowel Disease: A Review.

Cureus·2026

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The "clonal selection hypothesis" and current concepts of B cell tolerance

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B-cell development.

Is tolerance the result of engaging surface Ig of B cells in cycle?

Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta.

Relative roles of somatic and Darwinian evolution in shaping the antibody response.

B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation.

Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chains.

Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism.

Group 2 innate lymphoid cells activate myelin-reactive T cells to augment neuroinflammation.

CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity.

Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors.

Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated microglia in neurodegenerative diseases.

Butyrophilin-like 3 and 8 tetramers clamp Vγ4Vδ1 T cell receptors for antigen-independent activation.

Life-Threatening Melena from Deep Ileal Angiodysplasia Successfully Treated by Intraoperative Enteroscopy-Guided Segmental Resection: A Case Report.

Immune checkpoint inhibitors in the real world: A service evaluation of immune-related adverse event incidence and blood test requesting at Portsmouth Hospitals University Trust.

[Current status of methods and proficiency in assays for islet autoantibodies].

A biparatopic antibody targeting the Cε2 and Cε3 domains of IgE disrupts IgE-FcεRI interaction.

Advancing Type 1 Diabetes Treatment: 3 PM-Oriented Innovations in Islet Transplantation and Biomaterial Engineering.

How Biologics Are Changing the Global Burden of Inflammatory Bowel Disease: A Review.

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The "clonal selection hypothesis" and current concepts of B cell tolerance

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