[Atherosclerosis obliterance; thrombolytic therapy]

Area of Science:

• Vascular Surgery
• Interventional Cardiology
• Thrombolytic Therapy

Context:

• Chronic arteriosclerosis obliterans was historically considered unresponsive to thrombolytic therapy.
• Direct infusion of thrombotic agents via vascular catheterization has shown improved efficacy.
• This study focuses on the iliac and femoropopliteal arterial regions.

Purpose:

• To evaluate the effectiveness of high-dose intra-thrombotic urokinase injection for chronic arteriosclerosis obliterans.
• To report outcomes based on extensive clinical experience since 1985.

Summary:

• High-dose urokinase (10,000 units/minute) was infused directly into thrombi using a catheter in 65 arterial lesions.
• Achieved an 85% initial success rate and a 72% cumulative 1-year patency rate.
• The average total urokinase dose administered was 620,000 units.

Impact:

• Demonstrates a viable and effective interventional approach for managing chronic arterial occlusive disease.
• Provides evidence supporting intra-thrombotic thrombolysis as a treatment option.
• Contributes to the understanding of optimizing thrombolytic therapy for peripheral arterial disease.