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[Treatment of arteriosclerotic obstruction by blood purification]
1Kidney Center, Tokyo Women's Medical College, Japan.
Insights
LDL adsorption effectively treats dyslipidemia in patients with lower extremity arteriosclerosis, improving circulation and relieving symptoms for over a year.
Area of Science:
- Cardiovascular Medicine
- Lipidology
- Vascular Surgery
Context:
- Dyslipidemia frequently complicates lower extremity arteriosclerosis, impacting patient outcomes.
- Current plasma purification techniques include whole-plasma exchange, double filtration plasmapheresis, and LDL adsorption.
- LDL adsorption offers specific removal of LDL cholesterol, making it a preferred clinical method.
Purpose:
- To evaluate the efficacy of LDL adsorption in managing dyslipidemia associated with lower extremity arteriosclerosis.
- To assess the clinical improvements and long-term maintenance of effects following LDL adsorption treatment.
Summary:
- LDL adsorption treatment, typically involving ten procedures over three months, normalizes total and LDL cholesterol levels.
- Patients experience improved circulation, evidenced by increased extremity temperature and enhanced plethysmography.
- Clinical benefits include symptom amelioration, such as reduced pain, ulcer healing, and increased walking distance.
Impact:
- LDL adsorption demonstrates significant clinical benefits for patients with arteriosclerotic obstruction and dyslipidemia.
- Positive effects on circulation and symptoms are maintained in 80-90% of patients for an average of 1.2 years post-treatment.
- This therapy offers a specific and effective approach to managing complex cardiovascular conditions.
Abstract:
Almost a half of the patients with arteriosclerotic obstruction in the lower extremities is complicated with dyslipidemia (a blood total cholesterol level > or = 220 mg/dl and/or LDL cholesterol level > or = 140 mg/dl). Currently available plasma purification technics which actively correct dyslipidemia are whole-plasma exchange, double filtration plasmapheresis and LDL adsorption. However, because of the advantage in specificity in removal of LDL cholesterol, the LDL adsorption is most frequently applied in clinical practice. As a result of the LDL adsorption treatment, ten procedures for approximately 3 months as a usual treatment, course, sch as warmness, amelioration in pain and/or disappearance of ulcer in the lower extremities, elongation of a walk distance are obtained. Normalization of a total and LDL cholesterol level is also achieved. A rise in extremity temperature and improvement in plethysmograph are observed. These favorite effects are maintained in 80 to 90% of the patients so treated, respectively in different symptoms even averagely 1.2 years after a completion of the treatment course.