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Peyronie's disease is associated with an HLA class II antigen, HLA-DQ5, implying an autoimmune etiology
1Department of Surgery, Scripps Clinic and Research Foundation, San Diego, La Jolla, California, USA.
Purpose:
Previous studies using serological (protein based) HLA typing methods suggested an association between various HLA antigens and Peyronie's disease. We used a molecular (deoxyribonucleic acid based) HLA typing method to determine whether Peyronie's disease is associated with class II HLA antigens.
Materials And Methods:
Class II HLA typing using the polymerase chain reaction-sequence specific primer method was performed in 31 patients with Peyronie's disease, 19 age matched urological patients with disorders other than Peyronie's disease and 75 major organ donor cadavers representative of the general population.
Results:
The frequency of HLA-DQ5 was significantly increased in patients with Peyronie's disease (61% HLA-DQ5 positive) compared to age matched disease-free controls (11% HLA-DQ5 positive, corrected p = 0.003) and general population controls (25% HLA-DQ5 positive, corrected p = 0.005). The relative risk for Peyronie's disease associated with HLA-DQ5 was 12.7 and 4.6 compared to age matched and general population controls, respectively.
Conclusions:
This study shows a positive association for the HLA class II antigen HLA-DQ5 with Peyronie's disease, suggesting that HLA-DQ5 is a risk factor for Peyronie's disease and implying an autoimmune etiology for this disorder.
Insights
This study links the HLA-DQ5 antigen to Peyronie's disease, suggesting it as a risk factor. Molecular HLA typing indicates a potential autoimmune cause for this condition.
Area of Science:
- Immunogenetics
- Urology
- Autoimmune Diseases
Background:
- Previous serological studies suggested HLA antigen associations with Peyronie's disease.
- The etiology of Peyronie's disease remains incompletely understood, with potential autoimmune involvement.
Purpose of the Study:
- To investigate the association between class II HLA antigens and Peyronie's disease using molecular DNA-based typing.
- To determine if specific Human Leukocyte Antigen (HLA) antigens are risk factors for developing Peyronie's disease.
Main Methods:
- Molecular HLA typing, specifically polymerase chain reaction-sequence specific primer (PCR-SSP) method, was employed.
- Study included 31 patients with Peyronie's disease, 19 age-matched controls, and 75 general population controls.
Main Results:
- A significantly higher frequency of HLA-DQ5 was observed in Peyronie's disease patients (61%) compared to both age-matched (11%) and general population controls (25%).
- The relative risk for Peyronie's disease associated with HLA-DQ5 was substantially elevated (12.7 and 4.6, respectively).
Conclusions:
- The Human Leukocyte Antigen (HLA) class II antigen HLA-DQ5 is positively associated with Peyronie's disease.
- HLA-DQ5 is identified as a significant risk factor, supporting an autoimmune etiology for Peyronie's disease.