Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD28: a signalling perspective

S G Ward1

  • 1Department of Pharmacology, School of Pharmacy and Pharmacology, University of Bath, U.K.

The Biochemical Journal
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

This review details CD28 signaling pathways, crucial for T cell activation and immune responses. Understanding these cascades, including phosphoinositide 3-kinase, is key to regulating T cell functions like interleukin 2 production.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of infrared thermography and laser speckle contrast imaging for the dynamic assessment of digital microvascular function.

Microvascular research·2011
Same author

Collection, separation, and activation of human T lymphocytes.

Methods in molecular medicine·2011
Same author

Des-gamma-carboxy prothrombin stimulates human vascular endothelial cell growth and migration.

Clinical & experimental metastasis·2009
Same author

Des-gamma-carboxy prothrombin increases the expression of angiogenic factors in human hepatocellular carcinoma cells.

Life sciences·2008
Same author

Inhibition activity of sulfated polysaccharide of Sepiella maindroni ink on matrix metalloproteinase (MMP)-2.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2008
Same author

New drug targets in inflammation: efforts to expand the anti-inflammatory armoury.

British journal of pharmacology·2008
Same journal

Nanobodies against Plasmodium adhesins that block receptor engagement and malaria parasite invasion.

The Biochemical journal·2026
Same journal

Persistence without turnover: the RhoG G12E mutant highlights the role of nucleotide cycling in RhoG signaling.

The Biochemical journal·2026
Same journal

Alternative Splicing of Rice Chloroplastic CuZn Superoxide Dismutase, OsCSD2: Impact on expression and protein characteristics.

The Biochemical journal·2026
Same journal

Difference and similarity between the ubiquitous secretory pathway Ca2+-ATPases, SERCA2b, and SPCA1a.

The Biochemical journal·2026
Same journal

A molecular perspective on dimethylarginine dimethylaminohydrolases structure and function.

The Biochemical journal·2026
Same journal

Proteolytic coordination of the OXPHOS Life Cycle.

The Biochemical journal·2026
See all related articles

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Signaling

Background:

  • CD28 and CTLA-4, with ligands B7.1/B7.2, regulate immune responses.
  • CD28 signaling is essential for T cell activation, cytokine production, anergy, and programmed cell death.
  • CD28 signals are cyclosporin A-resistant and complement T cell receptor signaling for full T cell activation.

Purpose of the Study:

  • To review the structure and expression of CD28 and B7 families.
  • To detail the functional outcomes of CD28 ligation.
  • To elucidate the signaling events mediating CD28 functions.

Main Methods:

  • Review of existing literature on CD28 and B7 families.
  • Analysis of signaling cascades activated by CD28, including protein tyrosine kinase-dependent and -independent pathways.

Related Experiment Videos

  • Investigation of signaling cascades using pharmacological and genetic manipulations.

    • Main Results:

    • Multiple CD28-activated signaling cascades identified, including PLC, p21ran, PI3K, and sphingomyelinase.
    • The relative contributions of these cascades to CD28 signaling are dependent on T cell activation state and level.
    • CD28 signaling regulates transcription factors involved in interleukin 2 gene activation.

    Conclusions:

    • CD28 signaling is complex, involving multiple pathways with varying contributions.
    • Understanding CD28-mediated signaling is crucial for comprehending T cell activation and immune regulation.
    • Further research is needed to fully delineate the roles of specific signaling cascades in CD28 function.