[Study of the dithiocarbamate-basfungin, action on the body of pregnant white rats]

The authors carried out experiments on 120 pregnant rats and treated them oraly with basfungin in daily doses of 1/13 of LD50--1/100 of LD50. They examined the activity of serum enzymes-cholinesterase, glutamat-oxalacetic and glutamatryuvic transaminases, alkaline phosphatases, lactatdehydrogenase; in liver homogenates. They determined the content of sulphydryl and disulphide groups, cytochromexidase activity as well as pathomorophological studies on liver, thyroid gland, trachea, lung, myocardium, spleen and kidneys. There was reduced activity of cholinesterase, glutamatpyruvic transaminase, lactatdehydrogenase and elevated activity of alkaline phosphatase; inhibited activity of cytochromoxidase and reduced content of sulphydryl and disulfide groups in liver. The changes revealed marked dependence between dose and response. There were pathological findings only in liver, presenting manifested parenchymatous distrophy involving hepatocytes centraly located after administration of 250 mg of basfungine per kg of bogy weight, but after administration of 125 mg per kg of body weight there was only acute venous stasis.