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Membrane-bound tyrosine aminopeptidase activities in the rat brain throughout the estrous cycle
J M de Gandarias1, J Irazusta, D Fernández
1Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
Life Sciences
|January 1, 1996
Abstract:
Puromycin sensitive and insensitive membrane-bound aminopeptidase activity levels during the estrous cycle in several brain areas have been described in this research. We have found the highest aminopeptidase M activity levels during the proetrous stage in the hypothalamus, the amygdala and the pituitary gland. Since this enzyme has been involved in opioid peptide metabolism, it is suggested that aminopeptidase M could play a part in the decrease in the inhibitory influence of the endogenous opioids peptides that participate in the LH surge.