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Related Experiment Videos

Pregnancy and nursing

R Burakoff1, F Opper

  • 1Winthrop-University Hospital, Mineola, New York, USA.

Gastroenterology Clinics of North America
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Patients with inactive inflammatory bowel disease (IBD) can expect successful pregnancies. Active IBD during pregnancy increases risks, but safe medications and nutrition support are available for managing IBD during conception and gestation.

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Area of Science:

  • Gastroenterology
  • Obstetrics
  • Genetics

Background:

  • Inflammatory bowel disease (IBD) affects women of reproductive age.
  • Understanding the impact of IBD on fertility and pregnancy outcomes is crucial for patient counseling and management.

Purpose of the Study:

  • To review the current understanding of IBD's impact on fertility and pregnancy.
  • To provide guidance on the management of IBD during pregnancy, including medication safety and nutritional support.

Main Methods:

  • Literature review of studies on IBD, fertility, and pregnancy outcomes.
  • Analysis of data regarding the safety of IBD medications during gestation.
  • Evaluation of risks associated with active versus inactive IBD during pregnancy.

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Main Results:

  • Inactive IBD does not impact fertility or pregnancy course, though active IBD is linked to preterm delivery.
  • Active IBD during pregnancy increases risks of stillbirth and spontaneous abortion, but not congenital abnormalities.
  • Pregnancy does not typically worsen quiescent IBD; however, disease active at conception often persists or worsens.

Conclusions:

  • Women with inactive IBD should feel optimistic about pregnancy.
  • Corticosteroids, sulfasalazine, and 5-ASA are safe for maintaining remission; antimetabolites are not currently recommended.
  • Nutritional support (enteral and parenteral) and diagnostic imaging are safe and effective during pregnancy.