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Collagen type in dysfunctional temporomandibular joint disks
J P Gage1, R M Shaw, F B Moloney
1Department of Dentistry, University of Queensland, Brisbane, Australia.
The Journal of Prosthetic Dentistry
|November 1, 1995
Summary
This study found higher levels of Type III collagen in the temporomandibular joint (TMJ) disk attachments of women compared to men. These findings suggest women's TMJ tissues may be less resilient to functional loading.
Area of Science:
- Biochemistry
- Orthodontics
- Rheumatology
Background:
- The temporomandibular joint (TMJ) disk is crucial for jaw function.
- Dysfunctional TMJ disks are associated with pain and limited mobility.
- Understanding the biochemical composition of TMJ disks is key to addressing dysfunction.
Purpose of the Study:
- To analyze the collagenous fibrous tissue component of human temporomandibular joint disks.
- To identify and quantify collagen types within dysfunctional TMJ disk attachments.
- To investigate potential sex-based differences in TMJ disk composition.
Main Methods:
- Surgically removed dysfunctional human TMJ disks were analyzed.
- Collagenous residues were extracted using dissociative methods.
- Peptides were digested with cyanogen bromide and analyzed via electrophoresis and laser densitometry.
Main Results:
- Type III collagen was identified in posterior disk attachment tissues of both sexes.
- Women's TMJ disk attachments contained approximately twice the amount of Type III collagen as men's.
- Both sexes showed higher Type III collagen levels than previously reported for non-dysfunctional tissues.
Conclusions:
- Elevated Type III collagen in women's TMJ disk attachments may indicate reduced capacity to withstand functional loading.
- Sex-based differences in collagen composition could contribute to TMJ disk dysfunction.
- Further research into TMJ biomechanics and tissue resilience is warranted.