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Decrease in melatonin precedes follicle-stimulating hormone increase during perimenopause

O Vakkuri¹, A Kivelä, J Leppäluoto

¹Department of Physiology, University of Oulu, Kajaanintie, Finland.

European Journal of Endocrinology

|August 1, 1996

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Melatonin (hormone) secretion declines with age, particularly before menopause. This study suggests melatonin may play a role in initiating menopause due to its inverse relationship with follicle-stimulating hormone (FSH).

Area of Science:

Endocrinology
Reproductive Biology
Gerontology

Background:

Melatonin, a pineal gland hormone, inhibits aging in animal studies and decreases with senescence.
Menopause involves hormonal changes, including gonadotropin and sex steroid secretion.
The role of melatonin in menopausal hormonal regulation requires further investigation.

Purpose of the Study:

To investigate the potential role of melatonin in the hormonal regulation of menopause.
To analyze changes in melatonin and follicle-stimulating hormone (FSH) secretion during the menopausal transition.

Main Methods:

Cross-sectional study of 77 healthy females aged 30-75 years.
Melatonin measured via radioimmunoassay in nocturnal urine and morning blood serum.

Related Experiment Videos

Follicle-stimulating hormone (FSH) measured in morning blood serum.

Main Results:

Nocturnal urinary melatonin excretion significantly declined from premenopause to postmenopause.
Significant melatonin decline observed in women aged 40-44 years and 50-54 years.
Serum FSH levels rose sharply before age 50 and remained elevated; urinary melatonin correlated negatively with serum FSH.

Conclusions:

Inverse changes in melatonin and FSH secretion occur during perimenopause.
The sharpest decline in nocturnal melatonin excretion precedes menopause.
Melatonin may be permissively linked to the initiation of menopause.