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Updated: Aug 17, 2026

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
Published on: July 26, 2018
[Arrhythmias in patients with metabolic disease]
1Second Department of Internal Medicine, Kyorin University, School of Medicine.
Insights
Patients with diabetes mellitus often experience ventricular arrhythmias, a potential cause of sudden cardiac death. Reduced heart rate variability and increased QTc dispersion indicate higher arrhythmia risk in these patients.
Area of Science:
- Cardiology
- Diabetology
- Electrophysiology
Abstract:
Ventricular arrhythmias are frequently observed in patients with diabetes mellitus. On the other hand, diabetes mellitus has been associated with sudden death. Malignant ventricular arrhythmias might be one of the possible causes of sudden death. Prevalence of ventricular arrhythmias was increased with advancing severity of diabetes mellitus. The incidence of ventricular arrhythmias is closely related to occurrence of the disturbance of autonomic nervous system or the ischemic heart disease. Some papers and our present study indicate that the incidence of ventricular arrhythmias was associated with the decrease of the heart rate variability and the increase of QTc dispersion. Heart rate variability and QTc dispersion might be a good indicator of ventricular arrhythmias in patients with diabetes mellitus.
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