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[A case with perineuritis]

H Shimizu1, M Hujimoto, T Ohashi

  • 1First Department of Internal Medicine, Hamamatsu University School of Medicine.

Rinsho Shinkeigaku = Clinical Neurology
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

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This study details a rare case of perineuritis causing progressive sensory disturbances. High-dose corticosteroid treatment effectively improved symptoms and nerve function.

Area of Science:

  • Neurology
  • Pathology

Background:

  • Perineuritis is a rare inflammatory condition affecting the peripheral nervous system.
  • This case highlights a unique presentation of perineuritis with progressive sensory deficits.

Observation:

  • A 62-year-old woman presented with bilateral wrist and foot dysesthesia, hypalgesia, hypesthesia, and areflexia.
  • Neurological examination revealed distal-dominant sensory disturbances.
  • Nerve conduction studies showed absent sensory potentials, while sural nerve biopsy indicated perineurial thickening and mononuclear cell infiltration.

Findings:

  • Despite negative Borrelia burgdorferi antibodies and normal cerebrospinal fluid, the patient's symptoms and nerve biopsy were consistent with perineuritis.
  • Treatment with high-dose prednisolone (60 mg daily) led to gradual improvement in sensory disturbances and recovery of sensory nerve potentials.

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Implications:

  • This case underscores the importance of considering perineuritis in the differential diagnosis of unexplained peripheral neuropathies.
  • Aggressive corticosteroid therapy can be effective in managing perineuritis, leading to functional recovery.