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The two-way paradigm of transplantation immunology
A S Rao1, T E Starzl, A J Demetris
1Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
Clinical Immunology and Immunopathology
|September 1, 1996
Abstract:
The events following organ transplantation require a reciprocal cell interaction which includes both the conventional host-versus-graft reaction and a graft-versus-host component. With all successful transplantation, both graft and recipient become genetic composites. Where donors were available, chimerism has been confirmed in 30-year kidney-recipient survivors, as well as in several liver and lung recipients. A majority of liver recipients have been able to acquire an immunosuppressant-free state after 10-year survival. Animal models suggest that donor-derived cells may exert a tolerogenic effect.