Molecular genetics of bipolar disorder

Bipolar (BP) disorder is a severe mood disorder affecting about 1% of the population. Even though the traditional twin, family, and adoption studies have demonstrated that it is highly heritable, the specific vulnerability genes have so far escaped identification. The early years of molecular genetic studies in BP disorder were hampered by the complexities in the inheritance and phenotype of BP disorder, the poor marker maps and the low informativeness of DNA markers available at that time. The new developments in molecular genetics and statistical analysis methods for complex disorders have provided researchers with better tools to cope with these difficulties. During the past few years, several potential susceptibility loci have been reported in chromosomes 18, 21 and X, and the possible role of trinucleotide repeat expansions in the aetiology of BP disorder has been developed. It seems that the molecular genetics of BP disorder are entering a new era of rapid developments.