Leucocyte adhesion molecules in host defence against infection

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A Flow Adhesion Assay to Study Leucocyte Recruitment to Human Hepatic Sinusoidal Endothelium Under Conditions of Shear Stress
11:38

A Flow Adhesion Assay to Study Leucocyte Recruitment to Human Hepatic Sinusoidal Endothelium Under Conditions of Shear Stress

Published on: March 21, 2014

E J Brown1, F P Lindberg

  • 1Department of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.

Annals of Medicine
|June 1, 1996
PubMed

The destructive potential of leucocytes needs to be fully held in check in the circulation, while being released at the site of tissue destruction and infection. Leucocyte adhesion molecules are the key to this regulation, the recognition by the leucocytes of areas of tissue damage, and to transendothelial migration of leucocytes into these areas. The three classes of leucocyte adhesion molecules-the integrins, selectins and immunoglobulin superfamily members-are reviewed with their ligands and presented in the context of leucocyte migration, activation and host defence.

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