Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Telomere length regulation

C W Greider1

  • 1Cold Spring Harbor Laboratory, New York 11724, USA.

Annual Review of Biochemistry
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Telomeres protect chromosome ends, and their length is regulated by telomerase. In cancer cells, telomerase is active, highlighting its role in tumor progression and the need to understand telomere regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Telomerase RNA levels limit the telomere length equilibrium.

Cold Spring Harbor symposia on quantitative biology·2007
Same author

Telomerase and cancer stem cells.

Cold Spring Harbor symposia on quantitative biology·2006
Same author

Telomere length, telomere-binding proteins, and DNA damage signaling.

Cold Spring Harbor symposia on quantitative biology·2003
Same author

Cellular responses to telomere shortening: cellular senescence as a tumor suppressor mechanism.

Harvey lectures·2002
Same author

The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability.

Cell·2001
Same author

Tetrahymena proteins p80 and p95 are not core telomerase components.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same journal

Lactate as a Chemical Modification on Proteins and Metabolites.

Annual review of biochemistry·2026
Same journal

Nucleocytoplasmic Transport.

Annual review of biochemistry·2026
Same journal

Packaging of Single-Stranded RNA in Viruses and Virus-Like Particles.

Annual review of biochemistry·2026
Same journal

Shaping of the Infant Gut Microbiome by Milk Oligosaccharides.

Annual review of biochemistry·2026
Same journal

Proteostasis Deregulation by Metabolism Drives the Hallmarks of Cancer.

Annual review of biochemistry·2026
Same journal

JoAnne Stubbe's Radical Path: A Story of Passion, Curiosity, and Persistence.

Annual review of biochemistry·2026
See all related articles

Area of Science:

  • Genetics and Molecular Biology
  • Cell Biology

Background:

  • Telomeres are crucial for chromosome stability and complete DNA replication.
  • Telomere length is dynamically regulated by lengthening and shortening processes.
  • Telomerase, a ribonucleoprotein polymerase, is the key enzyme for telomere elongation.

Purpose of the Study:

  • To explore the role of telomerase in human cells, particularly in tumor progression.
  • To understand the complex regulation of telomere length by various cellular factors.
  • To investigate the interaction of factors influencing telomere length for a comprehensive understanding of telomere function.

Main Methods:

  • Review of evidence from various organisms regarding telomere length regulation.
  • Analysis of the role of telomere binding proteins, capping proteins, telomerase, and DNA replication enzymes.

Related Experiment Videos

  • Investigating the activity of telomerase in normal human tissues versus tumor cells.

    • Main Results:

    • Telomere length is not maintained in all human tissues due to lack of telomerase activity.
    • Telomerase is active in tumors, suggesting its essential role in cancer cell proliferation.
    • Several factors, including proteins and enzymes, interact to influence telomere length.

    Conclusions:

    • Understanding telomere length regulation and telomerase activity is vital for comprehending tumor progression.
    • The interplay between telomere-associated factors is critical for maintaining telomere function.
    • Further research into these interactions can illuminate telomere's role in cellular health and disease.