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Related Experiment Videos

Connexins, connexons, and intercellular communication

D A Goodenough1, J A Goliger, D L Paul

  • 1Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Annual Review of Biochemistry
|January 1, 1996
PubMed
Summary
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Cells communicate via gap junctions, formed by connexons. Research reveals molecular insights into connexin channel formation, permeability, and regulation by kinases and oncogenes.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cells communicate through gap junctions, which are intercellular channels facilitating the passage of ions and small molecules.
  • Gap junctions are assembled from connexons, protein complexes spanning adjacent cell membranes.
  • Connexons are composed of connexins, a multigene family with at least 13 members.

Purpose of the Study:

  • To elucidate the molecular mechanisms governing gap junction channel formation and permeability.
  • To understand the structure-function relationships of connexin diversity.
  • To investigate the regulation of connexins by signaling pathways.

Main Methods:

  • Analysis of connexin channel assembly mechanisms.
  • Structure-function studies of connexin proteins.

Related Experiment Videos

  • Investigation of connexin regulation by tyrosine kinases and oncogenes.

    • Main Results:

    • Identified selectivity in inter-connexin interactions during channel assembly.
    • Uncovered novel characteristics of gap junction channel permeability and gating.
    • Demonstrated unique regulation of connexins by tyrosine kinases and oncogenes.

    Conclusions:

    • Significant progress has been made in understanding the molecular switches controlling gap junction channels.
    • Connexin diversity plays a crucial role in cellular communication.
    • Connexin function is uniquely modulated by specific cellular signaling pathways.