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Related Experiment Videos

DNA workbench: a database package to manage regional physical mapping

P Nadkarni1, K H Cheung, C Castiglione

  • 1Center for Medical Informatics, Yale University School of Medicine, New Haven, CT 06510, USA.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|January 1, 1996
PubMed
Summary

DNA Workbench (DW) is a client-server database for managing chromosome physical mapping data. It visualizes DNA sequences at various resolutions, aiding genomic research and data organization.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Managing physical mapping data is crucial for chromosome sequencing and studying biologically significant regions.
  • Accurate data management supports large-scale genomic research efforts.

Purpose of the Study:

  • To introduce DNA Workbench (DW), a client-server database system designed for managing physical mapping data.
  • To provide a flexible tool for visualizing and organizing genomic information at different resolution levels.

Main Methods:

  • DW utilizes a client-server architecture for data management.
  • It offers two mapping modes: proportional (for known distances) and nonproportional (for order information).
  • User interaction is primarily through a graphical interface for data inspection and modification.

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Main Results:

  • DW effectively manages physical mapping data for specific chromosomal regions, such as DRD2 on chromosome 11 and HOX on chromosome 17.
  • The system supports dependency tracking and basic version control for map objects.
  • Users can interact with and modify underlying data through the visual map interface.

Conclusions:

  • DNA Workbench provides a robust solution for organizing and visualizing complex physical mapping data.
  • Its flexible mapping modes and user-friendly interface enhance genomic data management for research.
  • DW facilitates efficient handling of genomic information critical for sequencing and biological studies.