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Cutaneous mucor infection treated with wide excision in two children who underwent marrow transplantation
M E Trigg1, M A Comito, S L Rumelhart
1Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
Insights
Aggressive treatment, including wide surgical excision and antifungal therapy, is crucial for managing cutaneous mucor infections in pediatric leukemia patients undergoing bone marrow transplantation.
Area of Science:
- Mycology
- Hematology
- Pediatric Oncology
Background:
- Bone marrow transplantation (BMT) is a critical treatment for pediatric leukemia.
- Patients undergoing BMT are at high risk for opportunistic infections, including fungal infections.
- Cutaneous mucormycosis is a rare but severe fungal infection that can complicate immunosuppression.
Abstract:
Cutaneous mucor infection developed in two children who had undergone bone marrow transplantation for treatment of leukemia. One infection occurred before transplantation, and the other occurred during the period of profound neutropenia after transplantation. Both children were treated with an extensive wide excision of the infected area, and there was no evidence of mucor along the resected edges of tissue. Both patients received extensive treatment with either amphotericin (case 1) or amphotericin and itraconazole (case 2). These two cases represent aggressive management of cutaneous mucor infections, which is believed to be required for the successful completion of a marrow transplantation procedure.