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Updated: Aug 14, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Sister chromatid exchanges in balanced translocation carriers and in patients with unbalanced karyotypes
Abstract:
Sister chromatid exchanges (SCEs) were studied in peripheral human leukocytes from 16 patients with balanced translocations or with unbalanced karyotypes, and from 4 controls. No difference was seen between these two groups of people in the mean number of SCEs per cell, or in the total number of SCEs observed for each pair of autosomes involved in the translocations studied. With this last number no difference from the expected number of SCEs, if one supposes that SCEs follow a random distribution, was seen.
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The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
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Attachment of Sister Chromatids
Crossing Over
Nondisjunction