Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple mouse chromosomal loci for dynein-based motility

K T Vaughan1, A Mikami, B M Paschal

  • 1Cell Biology Group, Worcester Foundation for Biomedical Research, 222 Maple Avenue, Shrewsbury, Massachusetts, 01545, USA.

Genomics
|August 15, 1996
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of neuronal activity with cue-invariant shape discrimination in the primate superior temporal sulcus.

Neuroscience·2014
Same author

Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis.

Oncogene·2013
Same author

Isolation of digested sludge-assimilating fungal strains and their potential applications.

Journal of applied microbiology·2013
Same author

Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells.

Oncogene·2013
Same author

RNAi and iTRAQ reagents united: targeted quantitation of siRNA-mediated protein silencing in human cells.

Analytical and bioanalytical chemistry·2009
Same author

Differential activity to shapes under shape-from-motion condition in macaque middle temporal area.

Neuroscience·2008

Researchers mapped new dynein and dynactin genes in mice. This genetic mapping provides a foundation for understanding dynein

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Dyneins are motor proteins essential for cellular functions, including ciliary/flagellar movement and intracellular transport.
  • Dynactin is a protein complex that assists cytoplasmic dynein in its functions.
  • Understanding the genetic basis of these proteins is crucial for developmental and disease research.

Purpose of the Study:

  • To identify and map novel dynein genes within the mammalian genome.
  • To determine the chromosomal locations of previously identified dynein and dynactin genes in mice.
  • To establish a comprehensive genetic map for dynein and dynactin families in mammals.

Main Methods:

  • Identification of new dynein gene sequences.
  • Interspecific backcross analysis for chromosomal mapping in mice.

Related Experiment Videos

  • Comparative mapping of known dynein and dynactin genes.

    • Main Results:

    • Several new dynein genes were identified.
    • Accurate mouse chromosomal locations were determined for newly identified and previously known dynein and dynactin genes.
    • The study presents the first comprehensive mapping of dynein and dynactin genes in a mammalian system.

    Conclusions:

    • The comprehensive gene mapping provides a foundational resource for mammalian dynein and dynactin research.
    • This genetic information will facilitate future studies into the roles of dyneins and dynactins in development and disease.
    • The findings pave the way for targeted investigations into dynein-related disorders.