Related Experiment Videos
Repeated liver resection for recurrent liver cancer
1Department of Surgery, Lund University Hospital, Sweden.
The British Journal of Surgery
|July 1, 1996
Summary
Repeat liver resection offers a viable option for patients with recurrent colorectal metastases or hepatocellular carcinoma (HCC) confined to the liver. Selected patients can achieve survival rates comparable to initial liver resections.
Area of Science:
- Hepatobiliary surgery
- Surgical oncology
- Gastrointestinal oncology
Background:
- Cancer recurrence limited to the liver after initial resection presents a clinical challenge.
- Repeat liver resection is a potential treatment for selected patients with liver-only recurrence.
Purpose of the Study:
- To evaluate the outcomes of repeat liver resections for recurrent colorectal metastases and hepatocellular carcinoma (HCC).
- To assess survival rates, mortality, and morbidity associated with second and third liver resections.
Main Methods:
- Literature review of studies reporting on second and third liver resections.
- Analysis of data from 191 second and 10 third resections for colorectal metastases.
- Analysis of data from 128 second and 10 third resections for HCC.
Main Results:
- For colorectal metastases, 5-year survival was 26% (median 30 months), with 1.2% mortality and 27.4% morbidity.
- For HCC, 5-year survival was 40% (median 40 months), with 2.3% operative mortality and 13% morbidity.
- Longer intervals between resections and metachronous metastases correlated with better survival.
Conclusions:
- Repeat liver resection is a feasible option for carefully selected patients with liver-limited cancer recurrence.
- Outcomes of repeat liver resection can be comparable to those of initial liver resections.
- Patient selection and timing of resection are critical factors for successful outcomes.