Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Difference between the He bolus and N2 technique for measuring closing volume

D Stănescu, C Veriter, L Brasseur

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |June 1, 1977
    PubMed
    Summary

    Helium bolus measurements yield higher closing volumes than nitrogen, suggesting improved accuracy in assessing lung function. This method also reduces variability between observers for closing volume measurements.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Justification of CT scans using referral guidelines for imaging.

    Radiation protection dosimetry·2015
    Same author

    Differential diagnosis of abdominal wall defects - omphalocele versus gastroschisis.

    Chirurgia (Bucharest, Romania : 1990)·2014
    Same author

    Quantitative measurement of speech sound distortions with the aid of minimum variance spectral estimation method for dentistry use.

    Computer methods in biomechanics and biomedical engineering·2011
    Same author

    Beyond the magnetic domain matching in magnetic exchange coupling.

    Physical review letters·2010
    Same author

    [Treatment of acute peritonitis. Results in County Hospital Suceava with 317 cases ].

    Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2010
    Same author

    [Importance of enteral nutrition support in necrotic hemorrhagic pancreatitis].

    Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2010

    Area of Science:

    • Pulmonary Physiology
    • Respiratory Mechanics

    Background:

    • Closing volume is a measure of lung emptying.
    • Traditional nitrogen washout techniques may underestimate closing volume due to a less distinct vertical concentration gradient.

    Purpose of the Study:

    • To compare closing volume measurements using helium (He) bolus and nitrogen (N2) techniques.
    • To evaluate the impact of inspired oxygen on N2 closing volume.
    • To assess interobserver variability for both methods.

    Main Methods:

    • Closing volume was measured in healthy subjects and active workers using He bolus and N2 techniques.
    • N2 gradient was manipulated by varying inspired oxygen levels.
    • Interobserver differences in reading closing volumes were analyzed.

    Related Experiment Videos

    Main Results:

    • He closing volume was significantly higher than N2 closing volume in both groups.
    • Increasing the N2 gradient increased N2 closing volume, making it comparable to He closing volume.
    • Interobserver variability was lower for He closing volume measurements.

    Conclusions:

    • The He bolus method provides a more accurate assessment of closing volume compared to the N2 technique.
    • The He bolus method enhances measurement resolution and reduces interobserver variability, improving clinical utility.