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Related Experiment Videos

Impalpable prostate cancer: clinicopathological features

E Rogers1, J A Eastham, M Ohori

  • 1Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA.

British Journal of Urology
|March 1, 1996
PubMed
Summary

The study found that impalpable prostate cancers detected during transurethral resection of the prostate (TURP) are often small T1a tumors, while T1b cancers are increasingly detected by prostate-specific antigen (PSA) testing.

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Prostate cancer staging is crucial for treatment decisions.
  • Distinguishing between impalpable and palpable prostate cancers impacts management.
  • The advent of prostate-specific antigen (PSA) testing has influenced cancer detection rates.

Purpose of the Study:

  • To characterize the clinicopathological features of impalpable prostate cancer.
  • To evaluate changes in prostate cancer detection before and after PSA testing.
  • To assess the staging of prostate cancers found in radical prostatectomy specimens.

Main Methods:

  • Comparison of T1a and T1b prostate cancer detection rates in transurethral resections of the prostate (TURP) before and after PSA testing.
  • Analysis of T1 disease incidence in 400 radical prostatectomy specimens.

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  • Histopathological examination of prostatectomy specimens.

    • Main Results:

    • T1a cancer detection at TURP remained unchanged, while T1b detection decreased significantly post-PSA advent.
    • In radical prostatectomy specimens, T1b cancers were replaced by T1c and impalpable T2 cancers.
    • Ultrasonography plays a role in detecting impalpable T2 prostate cancers.

    Conclusions:

    • Incidental T1a cancers found during TURP may be candidates for conservative management.
    • T1b cancers are predominantly detected via PSA levels, leading to radical treatment.
    • T1c and impalpable T2 cancers exhibit distinct morphology from T1b disease, warranting separate staging.