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Synthesis of 2-isoxazoline and alpha-hydroxy ketomethylene dipeptide isosteres
1Department of Chemistry, Pohang University of Science and Technology, Korea.
Bioorganic & Medicinal Chemistry
|February 1, 1996
Abstract:
We have developed a simple and stereoselective method for synthesizing novel dipeptide isosteres using nitrile oxide cycloaddition as a key reaction. Employing this method, we have prepared efficiently various peptidomimetics containing 2-isoxazolines and alpha-hydroxy ketomethylene dipeptide isosteres.