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Related Experiment Videos

Multiple sclerosis with hydromyelia demonstrated at autopsy

B K Kleinschmidt-DeMasters1, J Newell

  • 1Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA.

Journal of the Neurological Sciences
|March 1, 1996
PubMed
Summary

This study provides the first pathological confirmation of a link between multiple sclerosis (MS) and intramedullary cysts. The findings detail a case of hydromyelia co-existing with chronic demyelinative plaques in MS.

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Area of Science:

  • Neurology
  • Pathology
  • Radiology

Background:

  • Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system.
  • Intramedullary cysts, previously diagnosed as syringomyelia, have been radiographically associated with MS in limited cases.
  • Histological confirmation of this association has been lacking.

Observation:

  • A patient presented with extensive hydromyelia of the thoraco-lumbar spinal cord.
  • The hydromyelia was co-existent with centrally located, non-necrotic, chronic demyelinative plaques.
  • Cerebral and cerebellar plaques were observed, with sparing of the optic chiasm, consistent with chronic, non-Devic type MS.

Findings:

  • This report provides the first pathological confirmation of the association between intramedullary hydromyelia and multiple sclerosis.

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  • The observed cysts were characterized as hydromyelia, not a dissecting syringomyelic cavity.
  • The study delineates the specific type of cyst associated with MS.

    • Implications:

    • This pathological evidence supports a connection between MS and intramedullary cysts.
    • Further research is warranted to understand the causal relationship, if any, between these two conditions.
    • The findings contribute to a better understanding of MS-associated spinal cord abnormalities.