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[Plasma fibronectin in pediatric patients]
I Maulén-Radován1, P Gutiérrez-Castrellón
1División de Investigación Clínica, Instituto Nacional de Pediatría, Secretaría de Salud, México, D.F.
Insights
Plasma fibronectin (FBN) levels are lower in pediatric patients, especially infants under six months. Low FBN may contribute to immunodeficiency in this at-risk group.
Area of Science:
- Biochemistry
- Pediatric Medicine
- Immunology
Objective:
To determine the levels of plasma fibronectin (FBN) in pediatric patients and to correlate them with serum albumin (ALB).
Methodology:
The FBN was measured by nephelometry and ALB by enzymatic analysis in samples from 95 healthy Mexican pediatric patients seen in the ambulatory surgery department.
Results:
The levels of FBN was similar in boy and girls (mean +/- SD) 273 +/- 90 and 268 +/- 106 micrograms/mL respectively. FBN was significantly lower in children less than 6 months old. We found seven patients with ALB < 3.0 g/dL who had significantly lower values of FBN than the normoalbuminemic patients. The correlation of FBN and ALB was low (r = 0.23).
Conclusions:
FBN in pediatric patients is significatively lower than in adults. The lowest concentrations were seen in children less than 6 months old. These lower FBN may be an additional factor for immunodeficiency in this group at risk.
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