[Strategy and results of treatment in trophoblastic disease]

The study involved 457 cases of ordinary (261), invasive (75) vesicular mole and choriocarcinoma (121-stage I-51.2; stage II-19.8 and stage III-27.3%). Enhanced chorionic gonadotrophin titer in urine was registered in 67-72%. Choriocarcinoma had no link to pregnancy in 6.6%. It is suggested that cases with a 10-year latency period and longer should be referred to this category of patients. Five-year survival was observed in 98-99% of patients with vesicular mole and in 74.1% with choriocarcinoma in 1977-1989. A special synoptic procedure has been developed for optimal planning the therapy and rehabilitation of cases of trophoblastic disease. Four forms of non-invasive vesicular mole have been identified, and strategies of treatment versus type of tumor and patient's peculiarities worked out. The extent of therapeutic effort has been decreased.