Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The evolution of hexokinases

T Ureta1, C Medina, A Preller

  • 1Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.

Archivos De Biologia Y Medicina Experimentales
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Biofilm-forming ability of Staphylococcus aureus on materials commonly found in milking equipment surfaces.

Journal of dairy science·2025
Same author

Fracture Resistance and Failure Mode of Polyethylene Fiber-reinforced Resin-based Restorations in Structurally Compromised Premolars: an in Vitro Study.

Operative dentistry·2024
Same author

Observation of Interatomic Coulombic Decay Induced by Double Excitation of Helium in Nanodroplets.

Physical review letters·2024
Same author

Clinical presentations and outcomes of HIV-1 and HIV-2 among infected children in Guinea-Bissau: a nationwide study.

Public health·2024
Same author

Biocidal effects of organometallic materials supported on ZSM-5 Zeolite: Influence of the physicochemical and surface properties.

Heliyon·2024
Same journal

[Hermann Niemeyer Fernández (1918-1991) and science in Chile].

Archivos de biologia y medicina experimentales·1992
Same journal

Society of Biology of Chile and the Associated Societies, 34th annual meeting. Puyehue, Chile, 27-30 November 1991. Abstracts.

Archivos de biologia y medicina experimentales·1991
Same journal

Sagaxine, the protamine from Sardinops sagax. Characterization, sequence and secondary structure prediction.

Archivos de biologia y medicina experimentales·1991
Same journal

Composition of the parotid saliva in Chilean children with Down's syndrome.

Archivos de biologia y medicina experimentales·1991
Same journal

[Concentrations of serum lipids in children with Down's syndrome].

Archivos de biologia y medicina experimentales·1991
Same journal

Assessing the scientific strength of Chile.

Archivos de biologia y medicina experimentales·1991
See all related articles

Hexokinases, enzymes that phosphorylate sugars using ATP, exhibit diverse specificities and molecular masses across organisms. Gene duplication events likely shaped hexokinase evolution, leading to distinct regulatory mechanisms and conserved sequences.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Enzymology

Background:

  • Hexokinases catalyze essential sugar phosphorylation reactions using ATP.
  • Enzymes range from sugar-specific kinases to less specific hexokinases.
  • Diversity in hexokinase structure, function, and evolutionary origins is observed.

Purpose of the Study:

  • To review recent advances in the structural and functional understanding of hexokinases.
  • To explore the evolutionary development of hexokinases, particularly in vertebrates.
  • To investigate the role of gene duplication in hexokinase evolution and regulation.

Main Methods:

  • Comparative analysis of hexokinase molecular masses (25 kDa, 50 kDa, 100 kDa) across different taxa.
  • Examination of hexokinase specificity, including sugar-specific, hexose-specific, and intermediate types.

Related Experiment Videos

  • Sequence comparisons of peptides from vertebrate hexokinase C and yeast hexokinases.

    • Main Results:

    • Hexokinases exhibit varied molecular masses (25, 50, 100 kDa) and specificities (e.g., glucokinase, fructokinase, mannokinasess).
    • Larger hexokinases (100 kDa) are found in vertebrates, while smaller ones are in microorganisms and invertebrates.
    • Product inhibition (glucose 6-P) in 100 kDa hexokinases suggests evolution of regulatory sites from duplicated active sites.
    • Sequence similarities between vertebrate and yeast hexokinases indicate conserved evolutionary pathways.

    Conclusions:

    • Gene duplication is a significant factor in the evolution of hexokinases.
    • The allosteric inhibition of vertebrate hexokinases points to functional divergence after gene duplication.
    • Conserved amino acid sequences suggest a slow evolutionary rate for homologous hexokinase genes.