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Experimental pyelonephritis in piglets: diagnosis with MR imaging
D J Pennington1, G J Lonergan, C E Flack
1Department of Radiology, PSRD, Wilford Hall U.S. Air Force Medical Center, Lackland Air Force Base, TX 78236-5300, USA.
Radiology
|October 1, 1996
Summary
Contrast-enhanced fast multiplanar inversion-recovery (IR) magnetic resonance (MR) imaging accurately detects experimental pyelonephritis in piglets. This sensitive and specific MR technique shows findings comparable to histopathologic examination.
Area of Science:
- Veterinary Radiology
- Medical Imaging
- Nephrology
Background:
- Pyelonephritis, a kidney infection, is challenging to diagnose non-invasively.
- Experimental models are crucial for evaluating diagnostic techniques.
Purpose of the Study:
- To compare magnetic resonance (MR) imaging findings with histopathologic examination for detecting experimentally induced pyelonephritis in piglets.
- To assess the diagnostic accuracy of various MR imaging sequences.
Main Methods:
- MR imaging was performed on piglets with and without experimentally induced pyelonephritis.
- Contrast-enhanced T1-weighted and fast multiplanar inversion-recovery (IR) sequences were utilized.
- MR images were independently reviewed by pediatric radiologists and compared with histopathologic findings.
Main Results:
- Coronal gadolinium-enhanced fast multiplanar IR imaging demonstrated high sensitivity (85-92%) and specificity (94-95%) for pyelonephritis detection.
- MR imaging findings were not statistically different from histopathologic results.
- Excellent interobserver reproducibility was achieved for the contrast-enhanced IR sequence.
Conclusions:
- Contrast-enhanced fast multiplanar IR imaging is a sensitive and specific diagnostic tool for experimental pyelonephritis in piglets.
- This MR technique shows promise for non-invasive diagnosis of kidney infections.