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does intravenous administration of human albumin prevent severe ovarian hyperstimulation syndrome?
1Department of Obsterics and Gynecology, Rambam Medical Center, Haifa, Israel.
Objective:
To report our experience with i.v. albumin as a means to prevent ovarian hyperstimulation syndrome (OHSS) in high-risk patients.
Design:
Retrospective case-series.
Setting:
University hospital-based IVF program.
Patients:
Five women undergoing controlled ovarian stimulation for IVF-Based on previous history and/or E2 measurements and number of ovarian follicles, these patients were considered to be at high risk for developing OHSS.
Interventions:
Intravenous albumin was given at the time of oocyte retrieval. Additional doses were given 12 and 24 hours later.
Main Outcome Measure:
Development of OHSS.
Results:
Four patients developed OHSS; two of them had the severe form of the syndrome.
Conclusions:
Severe OHSS may develop in high-risk patients despite the prophylactic administration of i.v. albumin.