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Endothelium activation related increase of soluble intercellular adhesion molecule-1 in human schistosomiasis. Lack
H Lejoly-Boisseau1, A D Blann, M Seigneur
1Laboratoire d'Immunologie et Biologie Parasitaire, Universiaté de Bordeaux II, France.
Abstract:
Soluble intercellular adhesion molecule-1 (sICAM-1) level was measured in sera from 41 patients with Schistosoma mansoni schistosomiasis and compared with the sICAM-1 level in 41 healthy subjects. A significant increase in serum sICAM-1 was observed in patients with schistosomiasis compared with control subjects. As they were inhabitants of the French Antilles, the patients were, however, not settled in a malaria endemic zone, allowing this cause of sICAM-1 enhancement to be eliminated. No correlation was found between the level of sICAM-1 and the schistosomiasis serological titre. Such results favour the hypothesis of an activation of vascular endothelial cells due to egg deposition.