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Related Experiment Videos

Supratentorial primitive neuroectodermal tumors in children

P B Dirks1, L Harris, H J Hoffman

  • 1Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Ontario, Canada.

Journal of Neuro-Oncology
|July 1, 1996
PubMed
Summary

This study on supratentorial primitive neuroectodermal tumors (PNETs) in children found extremely poor survival rates. Aggressive treatment including gross total resection and chemotherapy is recommended for better outcomes.

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Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Cancer Research

Background:

  • Supratentorial primitive neuroectodermal tumors (PNETs) are aggressive brain tumors in children.
  • Treatment outcomes for these tumors have historically been poor, necessitating further investigation.

Purpose of the Study:

  • To review the clinical characteristics and treatment outcomes of children diagnosed with supratentorial PNETs.
  • To identify prognostic factors and recommend optimal treatment strategies.

Main Methods:

  • Retrospective review of 36 children diagnosed with supratentorial PNETs between 1970 and 1995.
  • Analysis of patient demographics, tumor characteristics, treatment modalities, and survival data.

Main Results:

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  • The median survival was 23 months, with 5-year survival at 18%.
  • Younger age, subtotal resection, and lack of craniospinal radiation were associated with worse survival.
  • Gross total resection, chemotherapy, and craniospinal radiation (for older children) showed trends towards better survival.

    • Conclusions:

    • Aggressive surgical resection (gross total resection) followed by chemotherapy is recommended for all children with supratentorial PNETs.
    • Craniospinal radiation should be considered for children over 3 years of age.
    • Improved treatment strategies are crucial given the extremely poor survival rates.