Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac function under myocardial ischemia

S Murao, M Kakihana, Y Sugishita

    Japanese Heart Journal
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Coronary occlusion rapidly impairs heart function and increases lactic acid. Perfusion with non-oxygenated solution delayed cardiac depression, possibly by washing out accumulated lactic acid from the anoxic myocardium.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Isolation and Identification of a Pyrogallol Oxidase Producing Microorganism and the Enzyme Production.

    Bioscience, biotechnology, and biochemistry·2016
    Same author

    Purification and Characterization of Arctium lappa L. (Edible Burdock) Polyphenol Oxidase.

    Bioscience, biotechnology, and biochemistry·2016
    Same author

    Coriolus versicolor Laccase Catalyzes the Decarboxylation of 2-(4-Hydroxyphenyl)-glycine and 4-Hydroxymandelic Acid.

    Bioscience, biotechnology, and biochemistry·2016
    Same author

    Isolation and Purification of Ascorbate Oxidase from Acremonium sp. HI-25.

    Bioscience, biotechnology, and biochemistry·2016
    Same author

    A Novel Laccase Inhibitor, N-Hydroxyglycine, Produced by Penicillium citrinum YH-31.

    Bioscience, biotechnology, and biochemistry·2016
    Same author

    Autofluorescence (safe) bronchoscopy and p21/ki-67 immunostaining related to carcinogenesis.

    Photodiagnosis and photodynamic therapy·2014
    Same journal

    Cardiac wall motion abnormalities observed in a patient with transient hyperthyroidism.

    Japanese heart journal·2005
    Same journal

    A case of deep venous thrombosis with a double inferior vena cava effectively treated by suprarenal filter implantation.

    Japanese heart journal·2005
    Same journal

    Pulmonary and aortic valve endocarditis in an adult patient with silent patent ductus arteriosus.

    Japanese heart journal·2005
    Same journal

    A case of the toxicity of pilsicainide hydrochloride with comparison of the serial serum pilsicainide levels and electrocardiographic findings.

    Japanese heart journal·2005
    Same journal

    False-positive exercise test secondary to Wolff-Parkinson-White syndrome in the absence of manifest preexcitation and disappearance of ST depressions after accessory pathway ablation.

    Japanese heart journal·2005
    Same journal

    Reel syndrome and pulsatile liver in a patient with a two-chamber pacemaker.

    Japanese heart journal·2005
    See all related articles

    Area of Science:

    • Cardiovascular Physiology
    • Cardiac Metabolism

    Background:

    • Understanding myocardial response to ischemia is crucial for treating heart conditions.
    • Metabolic byproducts accumulate during reduced blood flow, impacting cardiac function.

    Purpose of the Study:

    • To investigate hemodynamic and metabolic changes during coronary occlusion versus perfusion with non-oxygenated solution.
    • To compare the effects of ischemia and anoxic perfusion on cardiac function and lactic acid efflux.

    Main Methods:

    • Anesthetized dogs underwent left circumflex coronary artery occlusion and perfusion with non-oxygenated Tyrode's solution.
    • Measured left ventricular pressures (LVSP, LVEDP), cardiac output (stroke volume), and myocardial segment length.
    • Calculated peak LV-dp/dt/IIP and lactic acid efflux into venous blood.

    Related Experiment Videos

    Main Results:

    • Coronary occlusion caused rapid declines in LVSP, stroke volume, and peak LV-dp/dt/IIP, with elevated LVEDP and systolic bulging.
    • Perfusion with non-oxygenated solution resulted in minimal changes in these parameters over 3 minutes.
    • Lactic acid efflux was significantly greater during non-oxygenated perfusion compared to occlusion.

    Conclusions:

    • Non-oxygenated perfusion delayed the onset of cardiac functional depression compared to occlusion.
    • The "wash-out" of accumulated metabolites, like lactic acid, may contribute to the delayed functional decline during anoxic perfusion.